Tirzepatide
Metabolic research; two gut-hormone receptors · From $65
Overview
Tirzepatide is a 39-residue acylated peptide built on a GIP scaffold that acts as a dual agonist at the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R), and has been characterised in the literature as an imbalanced and biased agonist with greater potency at GIPR than at GLP-1R. It is used in vitro to dissect GIPR/GLP-1R co-agonism through cAMP accumulation and β-arrestin recruitment in recombinant cell lines, and has been investigated in preclinical rodent models of energy balance and glucose handling.
- Purity
- ≥ 99%
- Form
- Lyophilized powder
- Class
- Acylated GIP-scaffold peptide
- Storage
- −20 °C, desiccated, dark
Also known as LY3298176, LY-3298176.
Research explained
The research interest
How one compound interacts with two hormone-receiving sites.
What was studied
The selected paper examines how tirzepatide activates two hormone-receiving sites in lab systems.
Evidence context
The source concerns laboratory signalling measurements. Compound research and testing this product are separate assessments.
Selected-source check, not a complete clinical review. No human-use recommendation.
Structure
Specifications
Identity
- CAS number
- 2023788-19-2
- Formula
- C225H348N48O68
- Molecular weight
- 4813.5 g/mol
- Chain length
- 39 residues
Material
- Purity, RP-HPLC
- ≥ 99%
- Form
- Lyophilized powder
- Appearance
- White to off-white lyophilized powder
- Vial sizes
- 5 mg, 10 mg, 15 mg
Handling
- Solubility
- Dissolves in aqueous buffer with sonication; DMSO used for concentrated laboratory stocks. Exact saturation concentrations not confirmed against a primary supplier datasheet.
- Storage
- Lyophilized powder sealed and protected from light and moisture: -20 °C for approximately 1 year, -80 °C for approximately 2 years. Reconstituted stocks: -80 °C short term. Avoid repeated freeze-thaw cycles.
Literature and research use
- Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonistPMID 32730231 · 2020
Citations describe published preclinical and in-vitro findings for this compound class and are not a representation about this material.
Research use only
All products listed on this site are supplied strictly as chemical reference materials for in-vitro laboratory research and are labelled For Research Use Only. They are not drugs, foods, cosmetics, or medical devices. They are not intended to diagnose, treat, cure, or prevent any condition, and are not for human or veterinary consumption or administration under any circumstances.
Research use policy ›$65
$13.00 per mg
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