Thymosin Alpha-1

Overview

Thymosin alpha-1 is an N-terminally acetylated 28-residue polypeptide originally isolated from thymic tissue fraction 5 and corresponding to residues 2-29 of prothymosin alpha. It is studied in preclinical and in-vitro systems as a modulator of innate and adaptive immune signalling, including Toll-like receptor 2/9-dependent dendritic cell activation, T-cell differentiation and cytokine expression, and has been used in cell-culture work probing PI3K/Akt/mTOR pathway signalling. The synthetic form (thymalfasin) is pharmacologically classified as an immunomodulatory peptide; catalog material is supplied for laboratory research use only.

Purity

≥ 99%

Form

Lyophilized powder

Class

N-terminally acetylated 28-residue linear polypeptide

Storage

−20 °C, desiccated, dark

Also known as Thymalfasin, Talpha1, TA1.

Research explained

Structure

Specifications

Literature and research use

1. Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signalingPMID 14982877 · 2004
2. Thymosin alpha1: an endogenous regulator of inflammation, immunity, and tolerancePMID 17495242 · 2007
3. Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathwayPMID 26002438 · 2015

Citations describe published preclinical and in-vitro findings for this compound class and are not a representation about this material.