TB-500

Overview

TB-500 is a synthetic acetylated heptapeptide reproducing the LKKTETQ actin-binding motif of the endogenous 43-residue actin-sequestering protein thymosin beta-4. It is used in preclinical and in-vitro work as a minimal-motif probe for G-actin binding and actin cytoskeletal dynamics, with reported literature endpoints including keratinocyte and endothelial cell migration and hepatic stellate cell activation. Note that the trade designation TB-500 is applied in the literature and commerce both to this heptapeptide fragment and to full-length recombinant thymosin beta-4, which are chemically distinct entities.

Purity

≥ 99%

Form

Lyophilized powder

Class

N-terminally acetylated heptapeptide

Storage

−20 °C, desiccated, dark

Also known as TB500, Ac-LKKTETQ, Thymosin beta-4 fragment 17-23.

Research explained

Structure

Specifications

Literature and research use

1. Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged micePMID 12581423 · 2003
2. Biological activities of thymosin beta4 defined by active sites in short peptide sequencesPMID 20179146 · 2010
3. Thymosin β4 inhibits PDGF-BB induced activation, proliferation, and migration of human hepatic stellate cells via its actin-binding domainPMID 30063851 · 2018

Citations describe published preclinical and in-vitro findings for this compound class and are not a representation about this material.