SS-31 (Elamipretide)

Overview

SS-31 (elamipretide) is a cell-permeable aromatic-cationic tetrapeptide containing a non-standard 2,6-dimethyltyrosine residue that concentrates in the inner mitochondrial membrane and binds cardiolipin. Preclinical and in-vitro studies examine its interaction with cardiolipin-cytochrome c complexes, the organisation of respiratory chain supercomplexes, electron transport efficiency, and mitochondrial reactive oxygen species generation, as well as age-associated post-translational modification of cardiac proteins in rodent models.

Purity

≥ 99%

Form

Lyophilized powder

Class

Cell-permeable aromatic-cationic mitochondria-targeting tetrapeptide

Storage

−20 °C, desiccated, dark

Also known as Elamipretide, MTP-131, Szeto-Schiller peptide 31.

Research explained

Structure

D-Arg-Dmt-Lys-Phe-NH2 (Dmt = 2,6-dimethyl-L-tyrosine; N-terminal D-arginine; C-terminal primary amide). CAS 736992-21-5 refers to the free base; acetate and trifluoroacetate salt forms carry separate registry numbers.

Specifications

Literature and research use

1. The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipinPMID 23813215 · 2013
2. Elamipretide (SS-31) treatment attenuates age-associated post-translational modifications of heart proteinsPMID 34480713 · 2021

Citations describe published preclinical and in-vitro findings for this compound class and are not a representation about this material.