Semax

Overview

Semax is a synthetic heptapeptide corresponding to the ACTH(4-7) fragment extended with a C-terminal Pro-Gly-Pro motif; it is non-corticotropic, lacking the steroidogenic activity of the parent melanocortin. Preclinical literature has examined its influence on BDNF protein levels and neurotrophin receptor gene transcription, dopaminergic and serotonergic turnover in rodent brain, and genome-wide transcriptional responses in rat models of focal cerebral ischemia. It is used in research as a tool compound for studying melanocortin-derived neuropeptide signalling.

Purity

≥ 99%

Form

Lyophilized powder

Class

Heptapeptide

Storage

−20 °C, desiccated, dark

Also known as ACTH(4-7)-PGP, ACTH4-7-PGP, Met-Glu-His-Phe-Pro-Gly-Pro.

Research explained

Structure

Specifications

Literature and research use

1. Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrainPMID 16635254 · 2006
2. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemiaPMID 19633950 · 2010
3. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysisPMID 24661604 · 2014

Citations describe published preclinical and in-vitro findings for this compound class and are not a representation about this material.