Selank
Stress-response and immune-signalling research · From $35
Overview
Selank is a synthetic heptapeptide analog of the endogenous immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg), extended at the C-terminus with a Pro-Gly-Pro motif that increases resistance to enzymatic degradation. It has been investigated in preclinical rodent models and cultured neuronal cell lines for effects on the expression of genes involved in GABAergic neurotransmission, monoamine turnover, and inflammation-related gene programs. In laboratory settings it is used as a probe of tuftsin-analog and GABAergic signalling pathways.
- Purity
- ≥ 99%
- Form
- Lyophilized powder
- Class
- Heptapeptide
- Storage
- −20 °C, desiccated, dark
Also known as TP-7, Tuftsin-PGP analog, Thr-Lys-Pro-Arg-Pro-Gly-Pro.
Research explained
The research interest
How peptide exposure relates to gene activity in the brain.
What was studied
The selected experiment measured changes in brain-related genes in rats.
Evidence context
This source concerns rats and gene measurements. Its scope is brain biology in an animal model.
Selected-source check, not a complete clinical review. No human-use recommendation.
Structure
Specifications
Identity
- CAS number
- 129954-34-3
- Formula
- C33H57N11O9
- Molecular weight
- 751.9 g/mol
- Chain length
- 7 residues
Material
- Purity, RP-HPLC
- ≥ 99%
- Form
- Lyophilized powder
- Appearance
- White to off-white lyophilized powder
- Vial sizes
- 5 mg, 10 mg
Handling
- Solubility
- Soluble in water; also soluble in DMSO. Compatible with aqueous buffers for in vitro assay preparation.
- Storage
- Lyophilized powder stored at -20 °C, desiccated and protected from light. Solutions should be aliquoted and held at -80 °C to limit freeze-thaw cycles.
Literature and research use
- Selank Administration Affects the Expression of Some Genes Involved in GABAergic NeurotransmissionPMID 26924987 · 2016
- GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 CellsPMID 28293190 · 2017
- The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank actionPMID 24291245 · 2014
Citations describe published preclinical and in-vitro findings for this compound class and are not a representation about this material.
Research use only
All products listed on this site are supplied strictly as chemical reference materials for in-vitro laboratory research and are labelled For Research Use Only. They are not drugs, foods, cosmetics, or medical devices. They are not intended to diagnose, treat, cure, or prevent any condition, and are not for human or veterinary consumption or administration under any circumstances.
Research use policy ›$35
$7.00 per mg
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