KPV (Lys-Pro-Val)

Overview

KPV is the C-terminal tripeptide (residues 11-13) of alpha-melanocyte-stimulating hormone and retains the anti-inflammatory signaling activity attributed to the parent hormone while lacking melanocortin receptor agonism, so it does not produce the pigmentary or feeding-related effects associated with full-length alpha-MSH. It is investigated in preclinical and in vitro models as an intracellular-acting immunomodulatory peptide, with reported mechanisms including inhibition of NF-kappaB nuclear translocation and suppression of downstream pro-inflammatory cytokine transcription. Published primary work includes PepT1-mediated transport into intestinal epithelial cells and murine models of colonic inflammation.

Purity

≥ 99%

Form

Lyophilized powder

Class

Linear tripeptide

Storage

−20 °C, desiccated, dark

Also known as KPV, Lys-Pro-Val, L-Lysyl-L-prolyl-L-valine.

Research explained

Structure

Specifications

Literature and research use

1. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammationPMID 18061177 · 2008
2. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel diseasePMID 18092346 · 2008
3. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative ColitisPMID 28143741 · 2017

Citations describe published preclinical and in-vitro findings for this compound class and are not a representation about this material.