GHK-Cu (Copper Peptide)

Overview

GHK-Cu is the copper(II) chelate of the endogenous tripeptide glycyl-L-histidyl-L-lysine, originally isolated from human plasma. It is investigated in preclinical and in vitro systems as a copper-transport ligand and as a modulator of extracellular matrix gene expression, including studies of collagen and glycosaminoglycan/proteoglycan synthesis in cultured fibroblasts and in rodent wound models. Reported mechanistic work examines its Cu(II) binding affinity and redox behavior, and transcriptional effects on matrix metalloproteinase, antioxidant, and matrix-remodeling gene sets.

Purity

≥ 99%

Form

Lyophilized powder

Class

Copper(II) complex of a tripeptide (1:1 metallopeptide chelate)

Storage

−20 °C, desiccated, dark

Also known as GHK-Cu, Copper tripeptide-1, Cu-GHK.

Research explained

Structure

Specifications

Literature and research use

1. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+PMID 3169264 · 1988
2. Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu(2+)PMID 11121126 · 2000
3. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene DataPMID 29986520 · 2018

Citations describe published preclinical and in-vitro findings for this compound class and are not a representation about this material.