A synthetic analogue of the growth hormone-releasing hormone fragment GHRH(1-29) carrying four amino acid substitutions (D-Ala2, Gln8, Ala15, Leu27) that were introduced to reduce susceptibility to dipeptidyl peptidase IV and other proteolytic cleavage in vitro. It is investigated in preclinical and in-vitro systems as a GHRH receptor agonist, in studies of receptor binding, cAMP signalling in pituitary somatotroph preparations, and structure-activity relationships of GHRH fragment analogues. It is also used as a reference analyte in analytical and anti-doping method development for GHRH-analogue detection.

Purity: ≥ 99%
Form: Lyophilized powder
Class: Tetrasubstituted GHRH(1-29) analogue
Storage: −20 °C, desiccated, dark

Also known as Modified GRF (1-29), Mod GRF 1-29, CJC-1295 no DAC.

The research interest

How changes to a peptide affect hormone-releasing signals.

What was studied

The selected paper compares modified growth-hormone-releasing fragments in lab tests.

Evidence context

The source compares related fragments. The exact no-DAC material and the DAC version require separate interpretation.

Selected-source check, not a complete clinical review. No human-use recommendation.

Linear peptide, 29 residues. Blue basic · light blue acidic · gray polar · light gray nonpolar.

1YADAIFTQSY

11RKVLAQLSAR

21KLLQDILSR

29 residues · H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 (substitutions at positions 2, 8, 15 and 27 relative to GRF(1-29): D-Ala2, Gln8, Ala15, Leu27)

Identity

CAS number: 863288-34-0
Formula: C152H252N44O42
Molecular weight: 3367.9 g/mol
Chain length: 29 residues

Material

Purity, RP-HPLC: ≥ 99%
Form: Lyophilized powder
Appearance: White to off-white lyophilized powder
Vial sizes: 2 mg, 5 mg, 10 mg

Handling

Solubility: Soluble in water and in dilute aqueous acetic acid; compatible with DMSO and DMF for preparation of laboratory stock solutions
Storage: Lyophilized powder: store at -20 °C, desiccated and protected from light; -80 °C for long-term storage. Solutions: aliquot and store at -80 °C; avoid repeated freeze-thaw cycles.

Citations describe published preclinical and in-vitro findings for this compound class and are not a representation about this material.

Research use only

All products listed on this site are supplied strictly as chemical reference materials for in-vitro laboratory research and are labelled For Research Use Only. They are not drugs, foods, cosmetics, or medical devices. They are not intended to diagnose, treat, cure, or prevent any condition, and are not for human or veterinary consumption or administration under any circumstances.

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Overview

Research explained